We have professional and advanced research and production capacity for gp130/IL6ST reagents production, including Proteins, Antibodies, cDNA Clones, ELISA Kits,etc. All IL6ST products are produced in house and quality controlled.

Macrophage recruitment is essential for heart regeneration through the secretion of OSM, which promotes cardiomyocyte proliferation. As the coreceptor of OSM, gp130 activation is sufficient to promote cardiomyocyte proliferation by activating Yap through Src during heart regeneration. gp130 is a pot …

gp130 is a receptor component for IL-6, IL-11, IL-27, and IL-31, as well as for several cytokines that are important in development. 6 Targeted disruptions of the gp130 gene are lethal in early embryogenesis. The mice exhibit defects in myocardial, hematologic, and placental development. GP130 is a signal-transducing subunit shared by the receptors for the IL-6 family of cytokines (1-3). The binding of a ligand to its receptor induces the dimerization of GP130, leading to activation of the Jak tyrosine kinase and to tyrosine phosphorylation of GP130. Gp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the classI cytokine receptor family. Binding of IL-6 or IL-11 to either the membrane-anchored or soluble IL-6 R or IL-11 R, respectively, initiates the association of IL-6 R (IL-11 R) with gp130.

Gp130

2019-08-08 THE JOURNAL † RESEARCH † www.fasebj.org Myeloid cells require gp130 signaling for protective anti-inflammatory functions during sepsis Sara Dutton Sackett,*,†,1 Tobias Otto,*,1 Antje Mohs,* Leif E. Sander,*,‡,§ Sonja Strauch,* Konrad L. Streetz,* Daniela C. Kroy,* and Christian Trautwein*,2 *Department of Internal Medicine III, University Hospital Rheinisch-Westfalische Technische Cardiomyocyte-specific deletion of Yap in Myh6-gp130 ACT mice blocked the effect of gp130 activation–induced heart regeneration in juvenile mice. Gene therapy with adenovirus-associated virus encoding constitutively activated gp130 promoted cardiomyocyte proliferation and heart regeneration in adult mice after myocardial infarction. Gp130/JAK/STAT Pathway Model Report { Generated by the Bio-PEPA Workbench {Maria Luisa Guerriero December 16, 2008 1 Bio-PEPA model bind gl l 1 = [k 1 gp130 LIF LIFR] 2021-03-31 Recombinant Human gp130/IL6ST Protein (Met1-Ile618) ECD 10974-HCCH is expressed in HEK293 Cells. With high purity, high biological activity, high stability, and other superior features, you can use this Human gp130/IL6ST protein for relevant bioassay and related research. 2019-02-08 As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards.

Western Blotting Image 1: GP130 Antibody. Western blot analysis of extracts from NIH/3T3, PC12, COS and HeLa cells, using GP130 Antibody. 1/1 Image

Gene therapy with adenovirus-associated virus encoding constitutively activated gp130 promoted cardiomyocyte proliferation and heart regeneration in adult mice after myocardial infarction. Gp130/JAK/STAT Pathway Model Report { Generated by the Bio-PEPA Workbench {Maria Luisa Guerriero December 16, 2008 1 Bio-PEPA model bind gl l 1 = [k 1 gp130 LIF LIFR] 2021-03-31 Recombinant Human gp130/IL6ST Protein (Met1-Ile618) ECD 10974-HCCH is expressed in HEK293 Cells. With high purity, high biological activity, high stability, and other superior features, you can use this Human gp130/IL6ST protein for relevant bioassay and related research. 2019-02-08 As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards.

Glycoprotein 130 (also known as · gp130, · IL6ST, · IL6-beta or · CD130) is a transmembrane protein which is the founding member of the class of all cytokine

Cytokine Receptor Here, we investigate the cellular localization, regulation, and possible function of two IL-6 receptors (IL-6Ralpha and gp130) in mouse and human fallopian Sökning: "gp130". Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet gp130. 1.

Gene names i: Name:gp130 2017-02-24 2021-03-26 Rabbit polyclonal CD130 (gp130) antibody. Validated in WB, IHC, Flow Cyt and tested in Mouse, Human. Cited in 6 publication(s). Immunogen corresponding to synthetic peptide. CD130, CD130 antigen, CDw130, gp130, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form, oncostatin M receptor, IL-6 receptor subunit beta, IL-6R subunit beta, interleukin receptor beta chain, Interleukin-6 receptor subunit beta, Interleukin-6 signal transducer, Membrane glycoprotein 130, membrane glycoprotein gp130, Oncostatin-M receptor subunit alpha Since IL-6 employs the cytokine receptor gp130 to primarily activate the STAT3 pathway, here we evaluate whether gp130-dependent STAT3 activation modulates atherosclerosis. METHODS: High-fat diet-induced atherosclerosis was established in ApoE(-/-) mice crossed with gp130(F/F) knock-in mice displaying elevated gp130-dependent STAT3 activation and production of the APR protein, serum … 2003-06-27 We further show that two gp130-signaling cytokines, IL-6 and IL-27, impair the suppressive capacity of human Treg cells.
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Cited in 6 publication(s). Immunogen corresponding to synthetic peptide. CD130, CD130 antigen, CDw130, gp130, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form, oncostatin M receptor, IL-6 receptor subunit beta, IL-6R subunit beta, interleukin receptor beta chain, Interleukin-6 receptor subunit beta, Interleukin-6 signal transducer, Membrane glycoprotein 130, membrane glycoprotein gp130, Oncostatin-M receptor subunit alpha Since IL-6 employs the cytokine receptor gp130 to primarily activate the STAT3 pathway, here we evaluate whether gp130-dependent STAT3 activation modulates atherosclerosis. METHODS: High-fat diet-induced atherosclerosis was established in ApoE(-/-) mice crossed with gp130(F/F) knock-in mice displaying elevated gp130-dependent STAT3 activation and production of the APR protein, serum … 2003-06-27 We further show that two gp130-signaling cytokines, IL-6 and IL-27, impair the suppressive capacity of human Treg cells.

Syftet med denna studie var att mäta nivån av Oncostatin M (OSM) en gp130-cytokin i tandkörtelvätskan (GCF) och serum hos kroniska Pedistalbågsmontage Navpod instrumentpod GP130 för infälld montering av GPS, ekolod, radar och multifunktionsskärmar.
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1.Introduction:Applied to pumping such liquid which is clean, no solid matter or frictional matter, low viscous, noncorr..About Gp130 PS131 with Cover Automatic

All IL6ST products are produced in house and quality controlled. By immunoscreening a placenta cDNA expression library with antibodies to human gp130, followed by screening a myeloma cell line cDNA library, Hibi et al. (1990) cloned gp130. The deduced 918-amino acid protein has an N-terminal signal peptide, followed by a 597-amino acid extracellular region, a transmembrane domain, and a 277-amino acid cytoplasmic domain.

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Reciprocal regulation of gastrointestinal homeostasis by SHP2 and. STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med. 2002; 8:1089-1097.

Homo sapiens (Human) Status.